Proinflammatory and Profibrotic Mediators: Principal Effectors of Leiomyoma Development as a Fibrotic Disorder

Fibrotic extracellular matrix activates a profibrotic positive feedback loop.

Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive fibrotic scarring in the lung that ultimately leads to asphyxiation; however, the cascade of events that promote IPF are not well defined. Here, we examined how the interplay between the ECM and fibroblasts affects ...

iranian efl learners’ pragmatic development: a study of proficiency and textbook effect

در تحقیق حاضراین پرسش که آیا دانش کاربرد شناسی زبان آموزان ایرانی همگام با پیشرفت بسندگی زبانی آنها افزایش می یابد مورد مطالعه قرار گرفته و هم چنین به این پرسش که آیا زبان آموزان تعلیم دیده از طریق کتاب های تاپ ناچ و اینترچینج تفاوت معناداری از لحاظ سطح دانش کاربرد شناسی دلرند ، پاسخ داده شده است. در این تحقیق55 فراگیر زبان انگلیسی به عنوان زبان دوم ازطریق نمونه گیری در دسترس مورد مطالعه قرار گ...

Tuberculosis Endometritis Presenting as A Leiomyoma

Profibrotic mediators in tendon disease: a systematic review

BACKGROUND Tendon disease is characterized by the development of fibrosis. Transforming growth factor beta (TGF-β), bone morphogenic proteins (BMPs) and connective tissue growth factor (CTGF) are key mediators in the pathogenesis of fibrotic disorders. The aim of this systematic review was to investigate the evidence for the expression of TGF-β, BMPs and CTGF along tendon disease progression an...

Profibrotic interleukin-33 is correlated with uterine leiomyoma tumour burden.

STUDY QUESTION Are interleukin-33 (IL-33) serum levels higher in women with uterine leiomyoma compared with controls without leiomyoma? SUMMARY ANSWER Serum IL-33 is elevated in women with uterine leiomyoma and correlated with features of uterine leiomyoma tumour burden, namely fibroid number, size and weight. WHAT IS KNOWN ALREADY Uterine leiomyomas are the most common benign tumours in pr...